|
KMID : 0881720200350030284
|
|
Journal of Food Hygiene and Safety
2020 Volume.35 No. 3 p.284 ~ p.289
|
|
|
Immunostimulatory and Bone Health-Promoting Activities of Litsea japonica Fruit Extract
|
|
Park Sung-Jin
Kang Jun-Chul
Lee Da-Young
Cho Ju-Hyun
Yoon Min-Ho
|
|
|
Abstract
|
|
|
|
This study was performed with hot water extract (LJF-W) and 70% ethanol extract (LJF-70E) of Litsea japonica fruit to investigate the immunostimulatory activity and bone health-promoting effect of L. japonica fruit. The production of pro-inflammatory mediator (nitric oxide) and pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) in murine macrophage RAW264.7 cells were estimated to examine the immunostimulatory activity of the fruit extracts. The immunostimulatory activity of LJF-W was higher than that of positive control (geinsenosides). However, there was no effect in LJF-70E. Futhermore, both LJF-W and LJF-70E appeared to stimulate the proliferation of MC3T3-E1 cells, proving the effect as a bone health agent. From this result it could be presumed that L. japonica fruit extracts not only stimulate the immune system, but also the ability to promote bone health.
|
|
|
KEYWORD
|
|
|
Litsea japonica fruit extract, Immuno-stimulation, Bone-health
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|